Humans kill a lot of sharks. Like, A LOT OF SHARKS. More than three every second to be exact. If we keep it up, several shark species will be extinct within the next few decades.
What would happen in a world without sharks?
That’s the question posed in this week’s episode of It’s Okay To Be Smart. From ecosystems to food chains to depressing death tallies to how much a shark is worth in $$$, there’s plenty of brain chum to watch and share with your fellow shark lovers.
But wait! It gets better! I also teamed up with The Brain Scoop, SciShow, Veritasium, MinuteEarth, and Smarter Every Day to bring you a week’s worth of shark science.
Because lawyers, we’re calling it “Several Consecutive Calendar Days Dedicated to Predatory Cartilaginous Fishes" instead of… well, you know. And unlike certain cable TV channels, our videos are non-fearmongering, unsensationalized, and dedicated to celebrating and protecting sharks , not turning them into bloodthirsty monsters. This should go without saying, but all of the SCCDDPCF videos are 100% true, factual and not made up in the least bit, unlike some other shark-related programming.
Check out the full playlist of shark science videos from your favorite channels here, or you can watch it embedded below:
The importance of these predators cannot be over-stated. Say “No!” to shark fin soup!!!
Why are guys so obsessed with their dicks? We’ll be like “Mothers have the right to breastfeed their baby in public!” And without fail, dudes chime in with, “Does that mean I can pull my dick out in public? Can I urinate in public?” Chill the fuck out. This isn’t about your dick. You are already allowed to have your nipples out in public, sit the fuck down.
oh my GOD THANK YOU
A New Way To Control Tumor Growth
Almost all high-risk, poor-prognosis cancers have high infiltration of macrophages, immune system cells that promote tumor growth and metastasis by secreting growth factors required for tumor progression.
A new study in Molecular Cancer Research by scientists at the University of California, San Diego School of Medicine shows that an emerging class of anticancer treatments known as PI-3K inhibitors degrade the HIF1 alpha protein as well as block tumor-induced angiogenesis and inhibit pro-angiogenic factors secreted by macrophages. The study may offer a potential therapy for treating deadly hypoxic tumors.
“Our study indicates that PI-3K inhibitors are excellent candidates for the treatment of cancers where macrophages promote tumor progression,” said lead author Shweta Joshi, PhD, postdoctoral researcher. “This is good news because it means that some new cancer therapies may help patients in more ways than was initially realized.”
“These HIF1 proteins are major players in driving the cancer state,” said co-author Donald Durden, MD, PhD, professor and vice chair for research in the Department of Pediatrics and research director, Division of Hematology/Oncology at the UC San Diego Moores Cancer Center.
“Hypoxic regions of tumors are characterized by an increased accumulation of macrophages which contributes to tumor angiogenesis and tumor progression. That is why our observation is so important, because it reveals an entirely new way of controlling tumor growth promoted by macrophages.”
Above image: An electron micrograph of a macrophage.